You have a huge opportunity because we know how hard it is to fully, deeply learn a programming language, and by using the same language to perform all your work on the web - both on the client and on the server, you're in a unique position of advantage.
What changes is the ecosystem.
In the browser, most of the time what you are doing is interacting with the DOM, or other Web Platform APIs like Cookies. Those do not exist in Node.js, of course. You don't have the
window and all the other objects that are provided by the browser.
And in the browser, we don't have all the nice APIs that Node.js provides through its modules, like the filesystem access functionality.
Another big difference is that in Node.js you control the environment. Unless you are building an open source application that anyone can deploy anywhere, you know which version of Node.js you will run the application on. Compared to the browser environment, where you don't get the luxury to choose what browser your visitors will use, this is very convenient.
Another difference is that Node.js supports both the CommonJS and ES module systems (since Node.js v12), while in the browser we are starting to see the ES Modules standard being implemented.
In practice, this means that you can use both
import in Node.js, while you are limited to
import in the browser.